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潘达努斯 (Pandanus amaryllifolius Roxb.) 的抗菌潜力是什么 : 植物化学分析,抗氧化剂和分子对接研究

Dwi Kusuma Wahyuni¹, Gita Aqila Nuha¹, Tope Gafar Atere²

¹Department of Biology, Faculty of Science and Technology, Universitas Airlangga Surabaya, Surabaya, East Java, Indonesia.

|August 14, 2024

概括

潘达斯 (Pandanus amaryllifolius Roxb.) 是一种的植物. 乙醇提取物显示出显著的抗氧化和抗微生物特性. 这项研究确定了关键化合物及其机制,支持其作为天然抗菌剂的潜力.

科学领域:

药理学和植物化学
自然产品化学自然产品化学
抗微生物药物发现抗微生物药物发现

背景情况:

抗微生物耐药性需要开发新的治疗药物.
探索自然产品,比如Pandanus amaryllifolius Roxb. 这样的植物. 为新药发现提供了一个有前途的途径.
了解药用植物的植物化学成分和生物活性至关重要.

研究的目的:

为了研究 Pandanus amaryllifolius Roxb. 的抗氧化和抗菌潜力. 使用in silico和in vitro方法提取乙醇提取物.
确定提取物中存在的生物活性化合物并阐明它们的潜在作用机制.
评估提取物对大肠杆菌和金黄色葡萄球菌等细菌病原体的疗效.

主要方法:

植物化学查,气色谱-质谱 (GC-MS) 用于化合物识别.
在基分子对接研究中,以预测与蛋白的结合亲缘关系.
在体外抗氧化剂测定 (DPPH,ABTS) 和抗菌活性评估 (井扩散).

主要成果:

植物化学分析显示了高黄素和多醇含量.
GC-MS确定了52种生物活性物质,包括n-hexadecanoic酸和neophytadiene.
提取物显示出显著的抗氧化活性 (IC50:DPPH的11.96μg/ml,ABTS的26.18μg/ml) 和对大肠杆菌和金黄色杆菌的抗菌作用.

结论:

潘达斯 (Pandanus amaryllifolius Roxb.) 是一种的植物. 乙醇提取物具有显著的抗氧化和抗菌特性.
已识别的化合物具有很高的结合亲和力,这表明抗菌作用的机制.
这些发现支持P. amaryllifolius Roxb.的潜力. 作为开发天然抗菌剂的来源.

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