相关实验视频
Updated: Jun 17, 2025
10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
19.4K
在新生儿死性肠球炎的诊断中, prokineticin 2 的临床价值
Qiuli Zeng1,2,3,4, Li Zeng1,2,3,4, Xiaoyan Yu1,2,3,4
1Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, China.
概括
在新生儿中诊断死性肠球炎 (NEC) 是具有挑战性的. 在NEC患者中,血清PK2水平显著降低,并且显示出比PCT和CRP更高的诊断疗效,特别是当它们结合使用时.
科学领域:
- 新生儿医学 新生儿医学
- 生物标志物发现发现
- 胃肠病学 胃肠病学
背景情况:
- 结核性肠球炎 (NEC) 是一种严重的肠道疾病,影响早产和低出生体重的婴儿.
- 目前的诊断方法缺乏针对NEC的特定血清生物标志物.
研究的目的:
- 为了调查NEC血清PK2水平的诊断疗效.
- 将PK2与PCT和CRP等现有生物标志物进行比较.
主要方法:
- 使用ELISA分析了来自NEC患者和健康新生儿对照的血清样本.
- 测量PK2水平,并进行ROC曲线分析以评估诊断准确度.
主要成果:
- 与对照组相比,NEC患者的PK2血清水平显著降低.
- 比起PCT (AUC=0.662) 和CRP (AUC=0.552),PK2的诊断效果更高 (AUC=0.837) 的证据显示.
- 将PK2与PCT和CRP结合使用,可以达到最高的诊断准确度 (AUC=0.981).
结论:
- 血清PK2是新生儿NEC诊断的一个有前途的生物标志物.
- 结合PK2与PCT和CRP,显著提高了NEC的诊断效率.
相关概念视频
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
154
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
154
01:19Depolarizing Blockers: Pharmocokinetics
316
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
316