同源性造血细胞移植与降低的毒性条件为儿科B型淋巴细胞恶性瘤
Yuki Naito1, Shinya Osone, Kohei Mitsuno
1Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Journal of pediatric hematology/oncology
|August 14, 2024
概括
降低毒性调节疗法 (FLAMEL) 对患有淋巴细胞恶性瘤的儿童进行全原造血细胞移植 (HCT) 是有前途的. 在HCT之前的负最小残留疾病 (MRD) 对于持续缓解至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 造血干细胞移植 造血干细胞移植
- 恶性瘤研究研究
背景情况:
- 在异性HCT之前,对于儿科淋巴细胞恶性瘤的常规调节方案是骨髓损伤性.
- 在这些疗法中,高剂量全身辐射 (TBI) 与显著的晚期并发症有关.
研究的目的:
- 评估在患有淋巴细胞恶性瘤的儿童中降低毒性调节方案 (FLAMEL),这些儿童接受全源性HCT.
- 评估FLAMEL在该患者群体中的疗效和安全性.
主要方法:
- 在HCT之前,一个由5名患有淋巴细胞恶性瘤的儿科患者组成的队列接受了FLAMEL治疗方案 (fludarabine,cytarabine,melphalan,低剂量TBI).
- 移植后对患者的结果进行了监测,包括缓解状态和复发.
主要成果:
- 五分之四的患者在18至63个月内实现并保持完全缓解.
- 在HCT之前,单个阳性最小残留疾病 (MRD) 的患者经历了复发.
结论:
- 在儿童淋巴细胞恶性瘤中,FLAMEL疗法可能是一个适合的替代品.
- 在HCT前的MRD消极性似乎是FLAMEL疗法的成功结果的关键因素.
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