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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

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大脑-计算机接口的寿命长度用于肌缩侧面硬化症.

Mariska J Vansteensel¹, Sacha Leinders¹, Mariana P Branco¹

¹From the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).

The New England journal of medicine

|August 14, 2024

概括

这项研究追踪了大脑与计算机接口 (BCI) 在7年内在肌缩侧面硬化症 (ALS) 中的通信. 最终,神经退行导致BCI信号下降和无效,尽管最初的成功.

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科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
神经学神经学

背景情况:

脑电脑接口 (BCI) 在患有进展性神经退行性疾病的个体中进行通信的长期有效性仍未得到充分探索.
肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,严重影响运动控制和沟通能力.

研究的目的:

评估植入BCI的耐用性和长期性能,以在7年内在晚期ALS患者中进行通信.
在渐进的神经退行症的背景下,研究导致BCI有效性最终下降的因素.

主要方法:

纵向案例研究报告了7年的独立家庭使用植入的BCI进行通信.
监测BCI使用频率,患者的功能状态 (眼神追踪) 和神经信号幅度.
计算机断层扫描 (CT) 图像,以评估大脑结构和神经退行.

主要成果:

在最初的6年中,BCI使用频率的初始增加,以弥补眼睛凝视控制的丧失.
随后的BCI使用逐渐减少,从6年左右开始,导致由于不可靠性而停止使用.
没有发现技术故障;由于神经信号幅度降低和与ALS相关的渐进性脑缩而导致的观察到的下降.

结论:

植入的BCI可以为患有ALS的个体提供多年来持续的通信.
渐进的神经退行,特别是神经信号幅度降低和大脑缩,最终可以限制BCI的有效性.
长期的BCI性能受到潜在疾病进展的影响,需要持续监测和潜在的适应策略.