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Updated: Jun 17, 2025

A High-content Assay for Monitoring AMPA Receptor Trafficking
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LGI1自身抗体通过前突触Kv1增强突触传播 损失和增加的行动潜力扩大突触传播

Andreas Ritzau-Jost1, Felix Gsell1, Josefine Sell1

  • 1From the Carl-Ludwig-Institute of Physiology (A.R.-J., F.G., T.K., S.M., S.H.), Faculty of Medicine, Leipzig University; Section Translational Neuroimmunology (J.S., C.G.), Department of Neurology, Jena University Hospital; Department of Biotechnology and Biophysics (S.S., C.W., M.S.), University of Würzburg, Biocenter, Germany; Institute of Science and Technology Austria (ISTA) (J.M., R.S.), Klosterneuburg, Austria; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, ; Department of Neurology (S.R.I.), John Radcliffe Hospital, Oxford University Hospitals, United Kingdom; and Departments of Neurology and Neurosciences (S.R.I.), Mayo Clinic Jacksonville, FL.

Neurology(R) neuroimmunology & neuroinflammation
|August 14, 2024
PubMed
概括

对氨酸丰富的质瘤失活1 (LGI1) 的自身抗体通过减少前突触Kv1.1和Kv1.2通道密度来增加神经递质释放,从而扩大了作用潜力. 这解释了LGI1自身免疫脑炎患者的神经元过活性的原因.

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