在日本人口中与催眠药多药性药物相关的因素
Akiyoshi Shimura1, Yoshikazu Takaesu2, Ko Sugiura3
1Japan Somnology Center, Neuropsychiatric Research Institute, 91 Bentencho, Shinjuku-ku, Tokyo, 162-0851, Japan; Department of Psychiatry, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan; Department of Psychiatry and Behavioral Science, Stanford University, 3165 Porter Drive, Palo Alto, CA, 94304, USA.
Sleep medicine
|August 14, 2024
概括
催眠多药是常见的,而二胺抗焦虑药物增加了风险. 避免这些并评估并发性疾病可以帮助预防多次睡眠药物处方.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 失眠障碍是一个重要的全球健康问题,经常用催眠药物来治疗.
- 长期使用二衍生物 (BZD) 和多种药物会带来依赖和滥用的风险.
- 了解催眠多药学的驱动因素对于患者的安全和有效治疗至关重要.
研究的目的:
- 调查在失眠障碍治疗中催眠多药学的因素.
- 分析人口统计因素,并发症和多种睡眠药物的使用之间的关联.
- 为了确定特定的药物类别与高风险的多药.
主要方法:
- 一项横截面研究分析了405,952名个人的匿名日本医疗保险数据 (2014年7月至2018年3月).
- 包括处方至少一种睡眠药物的门诊患者 (n=33,212).
- 层次逻辑回归评估了人口统计,并发症,药物类别和多药学之间的关联.
主要成果:
- 32.5%服用睡眠药物的患者接受了多种类型 (催眠多药).
- 多药性与年轻的年龄,特定的并发症和同时使用二胺抗焦虑药物 (ORs 8.01-9.39与BZD催眠药) 有关.
- 素受体对抗剂,黑激素受体激动剂和Z药物显示出较低的多药性几率 (ORs 0.74-0.87).
结论:
- 催眠多药在日本人口中很普遍.
- 建议在睡觉前评估并发症并避免使用二胺抗焦虑剂,以减轻多药性.
- 建议考虑与明智的处方一起考虑非药理疗法.
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