产前压力与后代炎症,抑郁和焦虑之间的关联
Zahra M Clayborne1, Stephen E Gilman2, Golam M Khandaker3
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Psychoneuroendocrinology
|August 14, 2024
概括
产前母亲的压力与更高的儿童IL-6水平以及青少年焦虑和抑郁有关. 然而,炎症标志物没有调解这种关联,这表明其他途径可能与心理健康结果有关.
科学领域:
- 发展心理学 发展心理学
- 神经免疫学 神经免疫学
- 流行病学 流行病学
背景情况:
- 产前母亲的压力是已知的不利于儿童发育的危险因素.
- 炎症在调解产前压力与青少年心理健康之间的联系中的作用需要进一步研究.
- 纵向研究对于理解心理健康的发展轨迹至关重要.
研究的目的:
- 调查产前母亲压力与青少年心理健康之间的联系.
- 检查儿童炎症 (IL-6和CRP) 在这种关系中的调解作用.
- 评估青少年普遍焦虑障碍 (GAD) 和抑郁症的症状.
主要方法:
- 利用了来自3723对母婴对的Avon长度研究父母和孩子 (ALSPAC) 的数据.
- 在怀孕期间通过55个项目评估产前母亲的压力.
- 在9岁时测量了胰岛素中介素-6 (IL-6) 和C反应蛋白 (CRP) 的血清度,并在16岁和18岁时测量了GAD/抑郁症状.
- 使用结构方程模型进行分析.
主要成果:
- 产前母亲的压力与童年IL-6度升高有关.
- 产前母亲的压力与青少年抑郁症和GAD症状的增加有关.
- 在产前母亲压力和CRP之间没有发现显著的关联,也没有在CRP/IL-6和青少年心理健康结果之间.
- 炎症标志物 (CRP和IL-6) 并没有调解产前压力与GAD或抑郁症之间的联系.
结论:
- 产前母亲的压力与儿童和青少年的心理健康问题中的特定炎症标志物 (IL-6) 有关.
- 儿童时期的炎症似乎并没有调解产前压力和青少年GAD或抑郁症之间的关系.
- 进一步的研究应该探索多个发育阶段的免疫活动,以充分了解与产前压力相关的长期心理健康风险.
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