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肠道微生物衍生代谢物和其他精选剂对脂肪细胞色的作用

Akankshya Nayak¹, Swati Sagarika Panda¹, Isha Dwivedi¹

¹School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India.

Biochemical and biophysical research communications

|August 14, 2024

概括

肠道微生物影响色脂肪的形成. 微生物代谢物显著提高了脂肪代谢和脂肪细胞中的色基因表达,显示了代谢疾病的治疗潜力.

科学领域:

代谢学代谢学代谢学
脂肪组织生物学脂肪组织生物学
微生物组研究微生物组研究

背景情况:

代谢性疾病在全球范围内正在上升,其特点是宿主代谢参数受到干扰.
肠道微生物群在色脂肪诱导中的作用已知,但机制尚不清楚.
肠道微生物群衍生代谢物 (元代谢物) 对于宿主微生物通信至关重要.

研究的目的:

为了验证肠道微生物群和色脂肪形成之间的相关性.
研究元代谢物对脂肪细胞分化和功能的影响.
为了比较元代谢物与已知的色脂肪诱导物的疗效.

主要方法:

治疗3T3-L1脂肪细胞细胞系的甲基代谢物从小鼠阴.
用L-Rhamnose和Ginsenoside作为积极对照的治疗.
对脂质代谢和色特异性基因表达的分析.

主要成果:

代谢代谢物显著增加脂质代谢和色特异性基因表达在脂肪细胞.
确定了一组可能调节脂肪细胞代谢活动的代谢物.
观察到的效果与L-Rhamnose和Ginsenoside的效果相似或超过.

结论:

微生物代谢产物在调节脂肪组织方面发挥着重要作用.
这项研究提供了关于连接肠道微生物群和色脂肪的机制的见解.
研究结果表明,针对微生物代谢物向代谢疾病的潜在治疗策略是微生物代谢物.

关键词:

白色脂肪组织脂肪组织.我们的肠道微生物群.脂质新陈代谢脂质新陈代谢代谢性疾病是一种代谢性疾病.代谢物的代谢物.代谢学代谢学代谢学

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