东亚人的身高和癌症风险:来自前性队列研究和门德尔随机化分析的证据
Yougen Wu1, Weimin Yu2, Yuting Gu1
1National Institute of Clinical Research, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Cancer epidemiology
|August 14, 2024
概括
更高的身高与东亚人的癌症风险增加有关. 这项研究发现身高与整体,肺癌,食道癌,乳腺癌和宫癌之间存在显著的关联,这表明身高可能是肺癌和胃癌的因果因素.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 身高是众所周知的各种癌症的风险因素,但东亚人口的数据有限.
- 这项研究通过调查东亚人身高与癌症的关联来弥补这一差距.
研究的目的:
- 评估东亚人群中身高与癌症风险之间的关系.
- 通过使用遗传数据,探索身高对癌症的潜在因果影响.
主要方法:
- 使用中国Kadoorie生物银行 (CKB) 预期队列的观察分析.
- 考克斯的比例危险模型用于估计调整的危险比率 (HRs) 和置信区间 (CI).
- 两个样本的孟德尔随机化 (MR) 分析,包括来自韩国基因组和流行病学研究 (KoGES),日本生物银行 (BBJ) 和CKB的数据.
主要成果:
- 身高增加10厘米与整体癌症 (HR 1.16),肺癌 (1.18),食道癌 (1.21),乳腺癌 (1.41) 和子宫癌 (1.29) 的更高风险显著相关.
- 身高也与淋巴瘤,结肠直肠癌和胃癌的风险增加有关.
- 核磁共振分析表明,基因预测的身高与肺癌和胃癌的更高风险之间存在暗示性关联.
结论:
- 更高的身高与几种癌症的风险增加有显著关系,包括整体癌症,肺癌,食道癌症,乳腺癌和子宫癌.
- 研究结果表明,身高可能是东亚人口肺癌和胃癌的潜在因果风险因素.
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