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与年龄相关的肉症和改变的肠道微生物群:系统性审查
Mengyu Wang1, Fangyuan Ren2, Yan Zhou2
1Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China.
Microbial pathogenesis
|August 14, 2024
概括
与年龄相关的肉症与肠道微生物群的变化有关. 有益的微生物可以通过影响关键代谢途径来改善肌肉功能并减缓肉症的进展.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 肌肉生理学 肌肉生理学
背景情况:
- 麻症,与年龄相关的肌肉衰退,显著影响老年人的健康.
- 肠道微生物群的改变越来越被认为是衰老和疾病的一个因素.
研究的目的:
- 系统地审查肠道微生物群对与年龄相关的肉症的影响.
- 为了确定与sarcopenia相关的关键微生物和代谢变化.
主要方法:
- 在2023年9月24日之前对出版物的系统审查.
- 搜索了PubMed,科学网,科克兰图书馆和Embase.
- 包括人类和动物研究检查肠道微生物群在sarcopenia.
主要成果:
- 分析了13项人类和8项动物研究.
- 麻的个体显示机会性病原体增加 (例如,Enterobacteriaceae) 和关键细菌的丰度发生变化.
- 观察到,参与短链脂肪酸,乌洛甲和胆酸代谢的有益细菌减少.
结论:
- 与年龄相关的肉症和肠道微生物群失调之间存在着强烈的联系.
- 代谢物,如短链脂肪酸,尿素甲和胆汁酸,在肠肌轴中起着至关重要的作用.
- 用有益的微生物准肠道微生物群可能为肉症提供治疗潜力.
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