来自皮质脊髓神经元的皮质othalamic输入有助于脊髓损伤后的慢性神经病痛
Ling Liu1, Zhihou Liang1, Lei Zhang1
1Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Experimental neurology
|August 14, 2024
概括
脊髓损伤 (SCI) 可以导致慢性神经病痛. 这项研究揭示了皮质脊柱侧面乳头通路对于SCI后发展和维持这种疼痛至关重要.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 神经病痛是脊髓损伤 (SCI) 的削弱后果,显著损害生活质量.
- 虽然涉及外周和脊柱机制,但脊柱上中心在慢性SCI疼痛中的作用仍然不清楚.
研究的目的:
- 调查脊上中心在SCI后神经病痛的发展和维持中的参与.
- 为了确定导致SCI相关慢性疼痛的特定神经回路.
主要方法:
- 验证了一种中度伤SCI表现出延迟慢性神经病痛的小鼠模型.
- 利用活动依赖的基因查来识别激活的脊柱上区域.
- 采用化学遗传学来禁用特定的神经元群体 (侧面丘脑).
- 使用逆行追踪来分析皮质体和皮质脊髓神经元活动.
- 研究了削减或沉默皮质脊髓神经元的影响.
主要成果:
- 在SCI诱导的神经病痛的小鼠中,通过触觉刺激激活多个皮层和皮下区域.
- 侧面 thalamus 神经元的化学遗传失活化减少了神经病痛和正常化的触觉引起的皮质过度活化.
- SCI诱导了增强的皮质体芽和皮质脊髓神经元的过度激活.
- 皮质脊髓神经元的切除或沉默可以防止慢性神经病痛的出现或持续.
结论:
- 一个皮质脊椎侧面的乳头前循环对于SCI后慢性神经病痛的发展和维持至关重要.
- 这些发现阐明了SCI疼痛的中心机制,并表明了创伤性大脑和脊髓损伤的潜在治疗点.
相关概念视频
01:28Major Somatic Sensory Pathways
929
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
929
01:29Overview of Somatic Sensory Pathways
4.3K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
4.3K
01:44Nociception
27.8K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.8K
01:11Direct Motor Pathways
1.9K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.9K
01:20Pain
471
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
471