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大多数口腔健康的元分析没有确和可靠的结果
Zacharias Tatas1, Elena Kyriakou2, Ourania Koutsiouroumpa3
1Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Bern, Switzerland.
Journal of dentistry
|August 14, 2024
概括
很少有口腔健康元分析使用哈顿和纳普 (HK) 校正或预测间隔 (PI). 这些方法提高了准确性,因为结果在应用时发生了显著的变化,影响了临床实践.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 生物统计学 生物统计学
- 基于证据的牙科.
背景情况:
- 只有少数研究的元分析往往对异质性的估计很差.
- 哈通和纳普 (HK) 校正和预测间隔 (PI) 解决了对异质性估计和未来试验效应大小的不确定性.
研究的目的:
- 评估口腔健康元分析中 HK 校正报告的使用情况.
- 将已公布的结果与使用八个异质性估计器和HK调整计算的结果以及PI进行比较.
主要方法:
- 分析了2021-2023年在牙科期刊上的系统评论 (SRs).
- 用八个异质性估计器重新分析了元分析,使用和不使用HK校正,并计算了PI.
主要成果:
- 只有3/292的元分析使用了HK调整;12/292报告了PI.
- 在使用不同的异质性估计器时,7.45%-16.59%的结果的统计意义发生了变化.
- 超过60%的显著元分析可能会根据PI在未来发生变化,其中超过40%包括相反的影响.
结论:
- 在元分析中,聚合估计的精度和意义对HK校正,异质性估计器和PI敏感.
- 对元分析估计的不确定性需要仔细考虑,特别是对少数或可变的研究.
- 误解结果可能导致不有效的临床干预.
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