室内空气污染会影响睡眠期间的心血管自主控制和炎症概况
Angelica Carandina1, Giacomo Fanti2, Alessio Carminati2
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza, 2023-2027, University of Milan, Milan, Italy; Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Environmental research
|August 14, 2024
概括
室内空气污染,包括挥发性有机化合物 (VOC) 和二氧化 (NO2),与健康成年人的心血管自主控制 (CAC) 损害和睡眠呼吸暂停事件有关. 暴露还会触发促炎和抗炎反应,突出显示空气质量是一个公共卫生问题.
科学领域:
- 环境健康 环境健康
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
背景情况:
- 心血管自主控制 (CAC) 和全身炎症对整体健康至关重要.
- 室内空气污染 (IAP) 是一个日益严重的公共卫生问题,可能会对健康产生影响.
- 了解IAP,CAC和炎症之间的关系对于预防策略至关重要.
研究的目的:
- 研究室内空气污染 (IAP) 在清醒和睡眠期间对心血管自主控制 (CAC) 的影响.
- 检查IAP暴露与全身炎症标志物之间的关联.
- 为了探索IAP和睡眠呼吸暂停事件之间的潜在联系.
主要方法:
- 20名健康的志愿者接受了为期7天的室内空气污染物 (PM2.5,NO2,VOC) 监测.
- 使用无线贴片记录了持续的心电图,呼吸活动和动图.
- 评估了CAC指数 (LF/HF,CVHRI) 和炎症生物标志物 (TREM-1,IL-10).
主要成果:
- 挥发性有机化合物 (VOC) 暴露与心率指数 (CVHRI) 的循环变化有积极的关联,表明睡眠呼吸暂停事件的潜在增加.
- 较高的CVHRI值与睡眠期间CAC向交感主导的转变相关.
- 二氧化 (NO2) 暴露与促进炎症 (TREM-1) 和抗炎症 (IL-10) 生物标志物的水平增加有关.
结论:
- 室内空气污染暴露可能会增加睡眠呼吸暂停事件的风险,并在睡眠期间损害心血管自主控制.
- 在健康个体中,IAP暴露会诱导复杂的炎症反应,具有亲和抗炎成分.
- 解决IAP对于公共卫生至关重要,特别是预防脆弱人群的慢性炎症和心血管问题.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
28
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
28
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Insufficient Sleep and Sleep Deprivation
138
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
138
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Disorders of the Autonomic Nervous System
590
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
590
Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376


