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含有辅酶Q10的微囊,稳定于糖单酸和大豆蛋白分离物-亚麻:特征,体外释放和消化行为:

Juan Huang¹, Shuo Zhang², Dongchen Liu²

¹School of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China; The East China Science and Technology Research Institute of Changshu Company Limited, Changshu 215500, China.

International journal of biological macromolecules

|August 14, 2024

概括

使用大豆蛋白分离物和亚麻的新型微囊有效稳定了辅酶Q10 (CoQ10). 这些微囊增强了CoQ10的含量.

科学领域:

食品科学与技术食品科学与技术
生物材料工程生物材料工程
营养药物输送系统营养药物输送系统

背景情况:

辅酶Q10 (CoQ10) 是一种具有有限生物可用性的脂友化合物.
稳定CoQ10对于其在功能性食品中的有效使用至关重要.
传统的输送方法往往面临着CoQ10稳定性和释放方面的挑战.

研究的目的:

开发和描述新型的微囊,以改善辅酶Q10的输送.
调查甘单酸 (GMS) 和亚麻 (FG) 在CoQ10封装和稳定性中的作用.
为了评估 CoQ10 装载微囊的体外释放特征和模拟消化.

主要方法:

复杂的联合化方法,使用大豆蛋白分离物 (SPI) 和亚麻 (FG) 作为墙壁材料.
核心材料包括甘单酸 (GMS) 和八/十甘酸,用于稳定CoQ10.
使用差分扫描热度计 (DSC),X射线衍射 (XRD) 和体外释放研究进行表征.

主要成果:

微囊形成了不规则的聚合物,其中CoQ10被困在半固体内核中.
GMS和FG显著提高了CoQ10加载和封装效率.
最初观察到爆发性释放,随后由Fickian扩散控制的持续释放.
证明了改善的CoQ10生物可访问性和良好的储存稳定性.

结论:

开发的SPI-FG微囊有效地保护和提供脂友性CoQ10.
GMS和FG在增强封装,持续释放和稳定性方面发挥着关键作用.
这种微封装策略有可能开发具有增加生物可用性的功能性食品.

关键词:

复杂的联合化.在体外模拟消化过程中模拟消化.释放机制释放机制

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