棕色海藻酸盐对抗氧化剂,抗癌,抗微生物和抗病毒性质的优化和表征
Mostafa El-Sheekh1, Wafaa M A Kassem2, Eman A Alwaleed2
1Botany Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt.
International journal of biological macromolecules
|August 14, 2024
概括
这项研究优化了棕色海藻的酸盐提取,从Dictyota dichotoma获得了最高的结果. 提取的酸盐显示出显著的抗氧化,抗癌和抗病毒特性.
科学领域:
- 海洋生物技术 海洋生物技术
- 自然产品化学 自然产品化学
- 生物聚合物是一种生物聚合物.
背景情况:
- 酸盐是一种来自棕色海藻的天然多糖,广泛用于营养药和制药行业.
- 优化酸盐提取对于最大限度地提高产量和纯度至关重要.
- 棕色海藻是有价值的生物活性化合物的丰富来源.
研究的目的:
- 为了优化从Padina pavonica中提取酸盐,使用盒式设计 (BBD).
- 为了在最佳条件下比较四种不同棕色海藻物种的酸盐提取产量.
- 评估提取的阿尔金酸盐的生物活性,包括抗氧化,抗癌和抗病毒性质.
主要方法:
- 盒式设计 (BBD) 优化温度,时间和度.
- 福利埃变换红外光谱 (FTIR),1H核磁共振 (NMR) 和高性能液体染色学 (HPLC) 用于表征.
- 在体外生物活性测定抗氧化剂,抗癌 (MCF-7细胞),抗微生物和抗病毒 (SARS-CoV-2) 活动.
主要成果:
- 确定了酸盐提取的最佳条件:度为2.5%,温度为39.95°C,时间为102.5分钟.
- 酸盐的产量因物种而异:P. pavonica (21.13%),S. cinereum (24.08%),T. turbinata (17.47%),以及D. dichotoma (19.57%).这些物种的产量都不同.
- 来自Dictyota dichotoma的酸盐表现出最强大的抗氧化,抗癌和抗病毒活性.
结论:
- 优化的提取方法显著提高了酸盐产量和质量.
- Dictyota dichotoma是高生物活性酸的一个有前途的来源.
- 提取的阿尔金酸盐由于其已证明的生物活性,因此有可能用于制药和营养药.
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