Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Framing Effects03:26

Framing Effects

7.3K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.3K
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

43.4K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
43.4K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

182
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
182
Adherens Junctions01:24

Adherens Junctions

4.7K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
4.7K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.6K
Attachment01:20

Attachment

58
Attachment is vital for infant development, as warm social interactions support growth and well-being. In a classic 1958 study by Harry Harlow, the significance of warmth and comfort in forming attachments was examined. Harlow separated newborn monkeys from their mothers and provided two artificial "mothers": one made of cold wire and the other covered in soft cloth. Despite the wire mother offering food, the infant monkeys preferred the comfort of the cloth mother, demonstrating that...
58

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ASO Visual Abstract: Clinical Impact and Outcomes of Neoadjuvant Systemic Therapy for Invasive Lobular Carcinoma.

Annals of surgical oncology·2026
Same author

Is Mastectomy Necessary in Patients with Occult Breast Cancer and Advanced (N2/N3) Nodal Disease?

Annals of surgical oncology·2026
Same author

ASO Visual Abstract: Is Mastectomy Necessary in Patients with Occult Breast Cancer and Advanced (N2/N3) Nodal Disease?

Annals of surgical oncology·2026
Same author

Clinical Impact and Outcomes of Neoadjuvant Systemic Therapy for Invasive Lobular Carcinoma.

Annals of surgical oncology·2026
Same author

Risk of malignancy after diagnosis of radial sclerosing lesion without atypia.

Breast cancer research and treatment·2026
Same author

Active monitoring versus surgical excision for atypical ductal hyperplasia.

Cancer prevention research (Philadelphia, Pa.)·2026
Same journal

Design and procedures for the greenness, cognitive performance and vascular outcomes in the northern Manhattan study (NOMAS-greenness).

American journal of epidemiology·2026
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
查看所有相关文章

相关实验视频

Updated: Jun 17, 2025

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

12.6K

对于粘附而言,可分离的效应是可分离的.

Kerollos Nashat Wanis1, Mats Julius Stensrud2, Aaron Leor Sarvet3

  • 1Department of Breast Surgical Oncology and Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.

American journal of epidemiology
|August 14, 2024
PubMed
概括
此摘要是机器生成的。

新的可分离效应对坚持 (SEA) 方法可以在患者坚持不同时改善药物有效性比较. 通过隔离坚持机制,SEA量化了治疗启动策略,提供了比传统的每协议方法更实用的方法.

关键词:
有关因果推理的推理.比较有效性研究比较有效性研究生命周期和生存分析.药学流行病学 药学流行病学

更多相关视频

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

11.5K
Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

469

相关实验视频

Last Updated: Jun 17, 2025

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

12.6K
Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

11.5K
Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

469

科学领域:

  • 药学流行病学 药学流行病学
  • 因果推理因果推理
  • 生物统计学 生物统计学

背景情况:

  • 由于患者的坚持率不同,比较药物有效性是具有挑战性的.
  • 传统的每条协议估计,在持续使用下评估有效性,当持续坚持很难实现时,有局限性.
  • 现有的方法很难将药物效应与坚持行为分开.

研究的目的:

  • 引入一个新的估计类:可分离的效应 (SEA).
  • 通过隔离坚持机制,提出量化药物启动策略的方法.
  • 为了提供一个更强大的框架来评估在现实世界的场景治疗的有效性与可变的坚持.

主要方法:

  • 开发了可分离的效应估计器,这些估计器修改药物以保持粘附元件不变.
  • 利用因果图来表示和询问关于治疗组件机制的假设.
  • 描述了构建可分离效应因果图的算法,并提出了半参数加权估计器.

主要成果:

  • 可分离的效果估计可以量化药物启动策略的有效性.
  • 该方法允许根据特定药物的坚持机制进行评估.
  • 因果图方便对识别这些影响所需的假设进行推理.

结论:

  • 对于坚持,可分离的效应提供了一个有价值的替代传统估计,当持续坚持是有问题的.
  • 这一框架提高了评估药物有效性的能力,并为启动策略提供了信息.
  • 提出的方法和因果图方法为药物流行病学研究提供了严格的基础.