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儿童败血症的负担和当代流行病学

R Scott Watson¹, Enitan D Carrol², Michael J Carter³

¹Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.

The Lancet. Child & adolescent health

|August 14, 2024

概括

败血症严重影响全球儿童,导致危及生命的器官功能障碍和长期健康问题. 解决儿科败血症对于儿童健康和实现全球发展目标至关重要.

科学领域:

全球儿童健康儿童健康
传染病流行病学传染病流行病学
儿科重症监护的儿童重症监护

背景情况:

败血症是由于感染而导致的危及生命的器官功能障碍,每年不成比例地影响5000万儿童.
儿科败血症导致显著的发病率,死亡率和发育潜力的丧失,影响全球儿童健康.
在诊断和治疗方面存在的挑战阻碍了减轻败血症对儿童和社会的负担的努力.

研究的目的:

综述儿童败血症在不同环境中的全球负担.
突出毒症评估的运行和新标准的影响方面的进展.
为改善败血症儿童的治疗结果提供路线图.

主要方法:

从低收入到高收入环境的儿科败血症负担的叙述性综述.
分析全球疾病负担估计和新评估标准的影响.
综合有关儿童败血症的诊断,治疗和后果的当前知识.

主要成果:

败血症是导致儿童发病和死亡的主要原因,并带来了巨大的社会成本.
败血症发病率和结果存在区域差异,不仅仅取决于收入.
败血症后的后续症状,包括神经发育障碍和生活质量下降,在儿童中很常见.

结论:

针对儿科败血症是改善儿童健康结果和实现可持续发展目标的关键.
需要标准化的评估和改进的治疗策略,以减少儿童败血症的全球负担.
对儿童的败血症后综合征进行进一步的研究对于全面的护理和长期的福祉至关重要.

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