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在一般瘤学PET/CT群体中对瘤活动的定量评估:哪个指标可以最大限度地减少标志物吸收时间的依赖性?

Semra Ince¹, Richard Laforest¹, Malak Itani¹

¹Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|August 14, 2024

概括

在PET成像中,标准化吸收值 (SUV) 和标准化吸收比 (SUR) 随着时间的推移而增加,而不是稳定的净流量率 (K). 吸收时间校正的SUV (cSUV) 和SUR (cSUR) 提供静态替代品,cSUR有效地预测K.

科学领域:

核医学是一种核医学.
放射化学放射化学是指辐射化学.
在瘤学瘤学.

背景情况:

在瘤PET成像中,标准化吸收值 (SUV) 和标准化吸收比 (SUR) 通常会随着时间的推移而增加.
从动态PET数据中得出的净流量率 (K) 预计将保持相对不变.
已提出采用时间校正的SUV (cSUV) 和SUR (cSUR) 作为K的静态替代品,旨在实现采用时间的独立性.

研究的目的:

量化K,SUV,cSUV,SUR和cSUR在PET/CT的恶性病变中的内扫描重复性.
探索cSUR估计K. 的能力.

主要方法:

对接受瘤PET/CT的成年人进行前性研究.
在注射后的两个时间点从动态PET数据中重建SUV和K图像.
手动细分瘤和提取定量指标,包括在60分钟的参考时间计算的cSUV和cSUR.

主要成果:

SUVmax和SURmax显示出较差的内扫描可重复性,这是由于早期到晚期的大幅增加.
对于[18F]FDG-avid病变,Kmax,cSUVmax和cSURmax表现出类似的内扫描可重复性.
对于DOTATATE-avid病变,Kmax和cSURmax显示了可比的内扫描重复性.
在不同时间点上,cSURmax与Kmax在两个标记剂中表现出最好的一致性.

结论:

与SUVmax和SURmax相比,Kmax,cSUVmax和cSURmax的吸收时间依赖性较低.
cSURmax可以有效地预测Kmax,为瘤学中的定量PET分析提供可靠的静态替代方案.

关键词:

在这里,PET是PET.帕特拉克坡道的斜坡纠正的SUVSUV进行了纠正.代谢速度代谢速度

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