利用癌症的见解来改善结核病治疗方法
Meenal Datta1, Laura E Via2, Véronique Dartois3
1Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Trends in molecular medicine
|August 14, 2024
概括
来自癌症治疗的洞察力为治疗结核病 (TB) 提供了新的策略. 通过向纤维化和缺氧等共同特征,宿主导疗法 (HDT) 与抗结核药物相结合可以提高疗效并减少副作用.
科学领域:
- 瘤学和传染病的研究
- 主体导向疗法 (HDT) 是一种主体导向疗法.
背景情况:
- 肺结核 (TB) 颗粒瘤和恶性瘤具有类似的微环境特征.
- 这些共同特征,包括纤维化,异常血管生成,缺氧,和免疫抑制,构成治疗挑战.
- 现有的结核病治疗方法在有效性和持续时间方面存在局限性.
研究的目的:
- 通过与瘤学进行并行研究,讨论结核病治疗发展的范式转变.
- 探索癌症疗法的应用,以克服结核病中共同的微环境异常.
- 提出一种新的框架,将高强度疗法与抗结核病药物结合起来.
主要方法:
- 综述和综合最近的研究,描述颗粒瘤和瘤之间的共同特征.
- 确定适用于结核病治疗的潜在癌症疗法.
- 组合治疗的概念框架开发.
主要成果:
- 可以针对共享的微环境因素,如过度纤维化,异常血管生成,缺氧,缩和免疫抑制.
- 癌症疗法,如矩阵向剂,抗血管原药和免疫刺激剂,对结核病有很大的前景.
- 组合策略可以提高治疗的交付和疗效.
结论:
- 利用瘤学的见解为结核病治疗开发提供了一种新的方法.
- 以适应的癌症疗法准共享的瘤-粒瘤微环境可以克服治疗耐药性.
- 结合高密度治疗和抗结核病剂的框架有望降低剂量,更短的持续时间,并减少结核病患者的副作用.
更多相关视频
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.8K
15:28A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
Published on: January 17, 2014
7.8K
相关概念视频
Pulmonary Tuberculosis V
174
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
174
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
