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基于最近的共识建议,对脑瘤成像使用脉冲化学交换和转移在3T进行功率等价连续近似的研究
Swee Qi Pan1, Yan Chai Hum1, Khin Wee Lai2
1Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kajang, Malaysia.
概括
脉冲化学交换和转移 (CEST) 的平均功率近似准确地模拟了低和功率,但在脑瘤成像中使用的高功率水平上显示了显著的差异.
科学领域:
- 磁共振成像是一种磁共振成像技术.
- 生物医学工程 生物医学工程
- 定量成像技术 定量成像技术
背景情况:
- 脉冲化学交换和转移 (CEST) 定量分析由于射频 (RF) 功率的变化而具有计算密集性.
- 连续近似的B1功率,像功率等效方法,用于加快分析.
- 高射频和功率 (B1=2.0μT) 建议用于临床脉冲CEST在3T,特别是对于脑瘤.
研究的目的:
- 调查使用平均功率 (AP) 作为脉冲CEST分析的连续近似的可行性.
- 在不同的射频和功率水平下评估AP近似的准确性.
主要方法:
- 对脉冲CEST数据进行模拟定量分析.
- 使用平均功率 (AP) 估计与基于完整模型的分析进行z光谱和装配参数的比较.
- 在低和高射频和功率场景中进行评估.
主要成果:
- 在低射频和功率场景中,AP连续近似表现出色.
- 在高射频和功率 (2.0μT) 的z光谱和拟合参数中观察到显著的差异.
- 在高和功率的情况下,注意到超过10%的差异,表明潜在的不准确性.
结论:
- 在高射频和功率水平下使用脉冲CEST的平均功率 (AP) 近似值时,建议谨慎使用.
- 在临床应用中,AP近似可能导致不准确的定量分析,例如在3T时对脑瘤进行成像.
- 为了准确的高功率脉冲CEST分析,需要进一步的验证或替代的近似方法.
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