鉴定基因风险得分和饮食模式之间的相互作用,以在基于人口的队列中个性化预防功能障碍
Min-Jae Jang1, Li-Juan Tan2, Min Young Park3
1Department of Animal Science and Technology, Chung-Ang University, Gyeonggi-do, 17546, Korea.
Nutrition & diabetes
|August 14, 2024
概括
高摄入量的"面粉和动物食品模式"与韩国成年人功能障碍风险增加有关,无论遗传风险分数如何. 考虑遗传特征的个性化饮食建议可能有助于管理脏疾病.
科学领域:
- 遗传学和流行病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 慢性病 (CKD) 是一种复杂的疾病,影响的结构和功能.
- 研究基因饮食相互作用对于理解CKD发育至关重要.
- 这项研究专注于韩国成年人来探索这些互动.
研究的目的:
- 检查与功能障碍有关的遗传倾向和饮食模式之间的相互作用.
- 在韩国人口中确定与功能障碍相关的特定饮食模式.
- 探索基于遗传风险的个性化营养策略的潜力.
主要方法:
- 利用了来自安山和安队列的8230名韩国成年人 (40-69岁) 的数据.
- 定义功能障碍为估计的膜过率<90毫升/分钟/1.73米2.
- 对1,590,162个SNP进行了全基因组关联研究 (GWAS),并计算了遗传风险得分 (GRS).
主要成果:
- 确定了三个饮食模式:谨慎,面粉/动物食品和白米.
- "面粉和动物性食品模式"显示,在低和高遗传风险组中,与较高的功能障碍患病率有显著的关联.
- 这种关联在不同的统计模型中仍然显著.
结论:
- "面粉和动物性食物模式"是韩国成年人功能障碍的重要饮食风险因素,无论遗传风险如何.
- 研究结果表明,遗传风险概况可以为预防功能障碍提供个性化的饮食建议.
- 这项研究支持开发基于GR的个人饮食模式,用于脏健康管理.
相关概念视频
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Human Genetics
551
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
551
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Renal Failure: Dose Adjustments
71
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
71
Factors Affecting Renal Clearance: Renal Impairment
63
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
63


