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在FINRISK队列中,肠道微生物群与事故骨折之间的关联

Louise Grahnemo¹, Oleg Kambur², Leo Lahti³

¹Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

NPJ biofilms and microbiomes

|August 14, 2024

概括

肠道微生物群的组成会影响骨折风险. 更高的多样性和Tenericutes的丰富性降低了风险,而蛋白质细菌,特别是蛋白质细菌,增加骨折风险,这表明微生物途径影响骨健康.

科学领域:

微生物组研究的研究.
骨健康和骨质疏松症
转基因组学是指转基因组学.

背景情况:

肠道微生物群 (GM) 影响骨质,但其在骨折风险中的作用尚不清楚.
了解转基因成分和骨折之间的关系对于开发新的预防策略至关重要.

研究的目的:

调查肠道微生物群组成和功能以及发生骨折的风险之间的关联.
确定与骨折风险相关的特定微生物种群和代谢途径.

主要方法:

在FINRISK 2002队列 (n=7043) 中使用了Cox回归模型,其中有1092例事件骨折病例和18年的随访.
分析了肠道微生物群的组成和功能,并使用了枪支元基因组测序.
评估了阿尔法和β多样性,类的相对丰富性 (蛋白质细菌,Tenericutes) 和特定的途径 (氨基酸代谢,脂多糖生物合成,丁酸盐合成).

主要成果:

更高的肠道微生物群α多样性与骨折风险降低有关 (HR 0.92).
蛋白质细菌 (特别是蛋白质细菌) 的相对丰度增加与骨折风险增加有关 (HR 1.14),而Tenericutes的丰度与风险降低相关 (HR 0.90).
参与氨基酸代谢和脂聚糖生物合成的微生物途径与骨折风险有关.

结论:

肠道微生物群的组成与发生骨折的风险有显著的关联.
特定的细菌类,蛋白质细菌和菌,以及它们的相关代谢功能,在骨健康和骨折易受性方面发挥着作用.
这些发现突出了肠道微生物群作为预防骨折的潜在治疗点.

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