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直接的视网膜-虹膜投射和内在虹膜收缩调解了早期脊椎动物的瞳孔光反射

Cecilia Jiménez-López¹, Paula Rivas-Ramírez¹, Marta Barandela¹

¹CINBIO, Universidade de Vigo, Neurocircuits Group, Campus Universitario Lagoas, Marcosende, 36310, Vigo, Spain.

Communications biology

|August 14, 2024

概括

兰普雷表现出一种独特的瞳孔光反射 (PLR),由直接的视网膜投射到虹膜介导,而不是大脑通路. 这种眼睛内在的机制,以及由黑色素驱动的肌肉收缩,表明早期的脊椎动物视觉系统进化了更简单的PLR功能.

科学领域:

神经科学是一个神经科学.
进化生物学进化生物学
眼科医生眼科眼科

背景情况:

瞳孔光反射 (PLR) 调节视网膜光暴露和脊椎动物的图像质量.
已知的两个PLR途径涉及脑介导电路 (视网膜-前膜-EWN-nIII-虹膜) 和虹膜内在的黑色素机制.
灯,与保存的视觉系统,提供了对PLR的进化起源的见解.

研究的目的:

通过研究鱼视觉系统机制来研究瞳孔光反射 (PLR) 的进化起源.
为了确定灯是否具有脑介导的或虹膜内在的PLR,或两者兼而有之.

主要方法:

用电生理学记录和药理学操纵来探测灯中的PLR途径.
研究了对虹膜的直接视网膜投射以及黑色素和间隙结在虹膜肌肉收缩中的作用.

主要成果:

兰普雷表现出一个直接的视网膜 - 虹膜胆固醇投射中介于PLR,这与之前关于大脑中介反射的假设相矛盾.
虹膜内在PLR,类似于其他脊椎动物,涉及黑色素和肌肉纤维之间的间隙结,与视网膜通路协同作用.
对脑中介的PLR通路 (通过埃丁格-韦斯特法尔核) 的证据在鱼中没有发现.

结论:

该研究表明,早期的脊椎动物进化可能具有两个眼睛内在的PLR机制:直接的视网膜输入和虹膜内在反应.
与眼睛内在机制相比,大脑介导的PLR途径似乎是一个较新的进化发展.

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