基于扩散加权成像,intravoxel不连贯运动和扩散曲解成像的直肠癌的病理预后因素
Mi Zhou1, Mengyuan Chen2, Mingfang Luo2
1Department of Radiology, Sichuan Provincial Orthopaedics Hospital, 610041, Chengdu, China.
European radiology
|August 14, 2024
概括
扩散曲解成像 (DKI) 显示了评估直肠癌预后的前景. 平均曲 (MK) 和其他DKI参数可以预测瘤分化,淋巴结转移和手术前血管入侵.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 结直肠癌的预后依赖于病理因素,如分化,淋巴结转移 (LNM) 和外壁血管入侵 (EMVI).
- 对这些因素进行准确的手术前评估对于治疗规划至关重要.
研究的目的:
- 评估扩散权重成像 (DWI),内无干运动 (IVIM) 和扩散曲解成像 (DKI) 在评估直肠癌患者的病理预后因素中的实用性.
- 确定DKI参数是否可以作为预测这些因素的非侵入性生物标志物.
主要方法:
- 一项前性研究包括162名接受彻底手术的直肠癌患者.
- 获得了DWI,IVIM和DKI参数,并与组织学差异化,LNM和EMVI相关联.
- 单变量和多变量逻辑回归,以及ROC曲线分析,用于评估成像参数的诊断性能.
主要成果:
- 较高的平均化 (MK) 和较低的明显扩散系数 (ADC) 与较差的瘤分化有关.
- 更高的 perfusion 分数 (f) 和更高的 MK 与淋巴结转移 (LNM) 相相关.
- 更高的f,更高的MK,更低的平均扩散率 (MD) 和更低的ADC与外壁血管入侵 (EMVI) 有关. 在分化方面,MK表现优于ADC,在LNM评估方面表现优于ADC. 结合MK和MD,显示出EMVI检测的最高准确度.
结论:
- 扩散曲解成像 (DKI) 参数,特别是平均曲解 (MK),显示出作为成像生物标志物的显著潜力,用于术前评估直肠癌预后因素.
- 这些发现表明,DKI可以帮助非侵入性评估瘤分化,LNM和EMVI,从而改善治疗策略.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
233
10:25Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
Published on: April 12, 2024
1.3K
相关概念视频
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
63
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
63