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Updated: Jun 17, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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依赖于Arid1a的正规BAF复合物抑制炎症程序,以驱动高效的生殖中心B细胞反应

Ajay Abraham1,2, Daniela Samaniego-Castruita1, Isabella Han1

  • 1Department of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.

Nature immunology
|August 14, 2024
PubMed
概括

含有正规BAF (cBAF) 复合物的AT丰富相互作用域1a (Arid1a) 对于生殖中心 (GC) 维护和抗体反应至关重要. 缺乏Arid1a会通过促进炎症,阻碍B细胞功能来损害GC程序.

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