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Updated: Jun 17, 2025

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合成,分子对接和抗炎评估的多元组件反应,新型的醇-醇混合衍生物的抗炎评估

Faeza Alkorbi1, Shareefa Ahmed Alshareef2, Mahmoud A Abdelaziz2

  • 1Department of Chemistry, Faculty of Science and Arts at Sharurah, Najran University, 68342, Sharurah, Saudi Arabia.

Molecular diversity
|August 14, 2024
PubMed
概括

研究人员合成了新型的 thiazol-indolin-2-one 衍生物,并测试了它们的抗炎作用. 化合物4b在体内表现出较高的抗炎活性,与塞莱科西布相比,表明其作为新疗法剂的潜力.

关键词:
它具有抗炎活性,具有抗炎活性.组织病理学检查印度尔衍生品 印度尔衍生品多元组件反应反应多元组件反应提亚醇 (Thiazole) 是一种可以

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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