患有骨关节炎的患者心血管健康和全因死亡风险之间的关联
Tao Liu1, Yaning Wang2, Tao Meng1
1Department of Bone and Joint Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong Province, 256600, China.
BMC musculoskeletal disorders
|August 14, 2024
概括
保持中度至高心血管健康 (CVH) 显著降低了骨关节炎 (OA) 患者因任何原因死亡的风险. 改善的CVH得分与OA患者更好的生存概率相关.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
背景情况:
- 骨关节炎 (OA) 是一种普遍的疾病,与死亡风险增加有关.
- 心血管健康 (CVH) 是影响整体健康结果的关键因素.
- 在OA患者中,CVH和死亡率之间的关系需要进一步调查.
研究的目的:
- 研究被诊断患有骨关节炎 (OA) 的患者心血管健康 (CVH) 和全因死亡风险之间的关联.
- 确定改善的CVH指标是否与OA的死亡率降低相关.
- 为改善OA患者的预后和管理策略提供见解.
主要方法:
- 一项队列研究利用了来自2007-2018年国家健康和营养检查调查 (NHANES) 的3642名OA患者 (年龄≥20岁) 的数据.
- 心血管健康 (CVH) 用生命的基本8 (LE8) 标准进行评估,包括饮食,体力活动,睡眠,BMI,血压,葡萄糖,脂质和尼古丁暴露.
- 全因死亡率通过国家死亡指数记录来确定,使用加权的COX比例危险模型和受限立方线 (RCS) 进行分析.
主要成果:
- 与低CVH患者相比,中度CVH (HR=0.67) 和高CVH (HR=0.47) 患者的全因死亡风险显著降低.
- 每增加10点的LE8得分与所有原因死亡风险比率的0.12降低有关 (HR=0.81).
- RCS曲线显示了剂量与反应的关系,LE8得分的增加与死亡风险的降低相关. 高CVH组的生存概率最高 (p=0.002).
结论:
- 心血管健康的中度至高水平与骨关节炎患者全因死亡风险较低显著相关.
- 这些发现强调了优化CVH作为改善OA患者生存结果的策略的重要性.
- 该研究为开发有针对性的干预措施提供了基础,以提高OA管理中的预后.
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