在全身性红斑狼患者中,感染与疾病活性相比发烧
Rasha A Abdel-Magied1, Nehal W Mokhtar1, Noha M Abdullah2
1Rheumatology, Rehabilitation and Physical Medicine Department, Minia University, Minia, Egypt.
BMC rheumatology
|August 14, 2024
概括
血红细胞沉积率与c反应蛋白 (ESR/CRP) 的比率以及中性粒细胞与淋巴细胞的比率 (NLR) 有效地诊断出患有发烧的全身性红斑狼 (SLE) 患者的感染. 这些标记物有助于区分感染与疾病活动.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 患有发烧的全身性红斑狼 (SLE) 患者在区分感染和疾病爆发时存在诊断上的挑战.
- 生物标志物,如甲素 (PCT),红细胞沉积率与c反应蛋白 (ESR/CRP) 比率,中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 等,都在研究它们的诊断作用.
研究的目的:
- 评估PCT,ESR/CRP比率,NLR和PLR在诊断发烧SLE患者感染中的作用.
- 评估这些标志物的诊断价值,以区分感染和SLE疾病活动.
- 检查这些标志物与SLE疾病活动的相关性.
主要方法:
- 一项研究包括40名SLE患者和40名健康对照.
- 疾病活动的评估是使用2000年系统性红斑狼疾病活动指数 (SLEDAI-2K) 进行的.
- 实验室测试包括全血细胞计 (CBC),ESR,CRP,PCT和计算比率 (NLR,PLR,ESR/CRP). 通过临床症状和阳性培养物证实了细菌感染.
主要成果:
- 与未感染患者相比,感染SLE患者在PCT,ESR,CRP,ESR/CRP比率和NLR中表现出显著差异.
- PCT,ESR,CRP和NLR与感染存在正相关;ESR/CRP比率显示出负相关性.
- 甲素 (PCT) 成为感染最强的预测因子 (OR 224.37),截止值为0.90 ng/ml,具有84.62%的灵敏度和85.71%的特异性.
结论:
- PCT,ESR/CRP比率和NLR是识别发烧SLE患者感染的有价值的诊断标记.
- 这些标志物有助于区分真正的感染和SLE人口中的疾病爆发.
- 在这个患者群体中,前素在预测感染方面表现出很高的准确性.
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