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Updated: May 4, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

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叶的动态功能连接和基因表达相关:从隐藏的马尔科夫模型的见解

Lu Qin1, Qin Zhou1, Yuting Sun1

  • 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Journal of translational medicine
|August 14, 2024
PubMed
概括

叶 (TLE) 显示大脑活动动态发生变化. 这项研究将TLE和TLE与认知障碍 (TLE-CI) 的这些时间变化与特定的基因表达模式联系起来.

关键词:
认知障碍 认知障碍是一种认知障碍.动态功能连接的动态功能连接基因表达 基因表达 基因表达隐藏的马尔科夫模型静止状态功能磁共振成像技术时间叶发作 时间叶.

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相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
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Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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