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门德尔随机化意味着表观遗传衰老加速与与年龄相关的眼睛疾病或青光眼内类型之间的因果关系

Jiawei Chen^1,2, Xiang-Ling Yuan^1,3, Xiaoyu Zhou^2,4

¹Aier Academy of Ophthalmology, Central South University, Changsha, 410015, Hunan Province, People's Republic of China.

Clinical epigenetics

|August 14, 2024

概括

表观遗传时钟显示与与年龄相关的眼睛疾病的因果关系,包括初级开角青光眼和与年龄相关的白内障. 这项研究强调了生物衰老.

科学领域:

遗传学和表观遗传学
眼科医生眼科眼科
老年学是一门学科.

背景情况:

由于人口老龄化,与年龄相关的眼睛疾病 (ARED) 是日益严重的全球健康问题.
基于DNA甲基化 (DNAm) 的表观遗传时钟是生物年龄的关键指标.
了解生物衰老和ARED之间的联系对于制定预防策略至关重要.

研究的目的:

调查表观遗传钟和常见的ARED之间的双向因果关系.
探索表观遗传钟和青光眼内类型之间的潜在因果关系.
为了确定青光眼内类型是否调解表观遗传钟和青光眼之间的关联.

主要方法:

利用欧洲人群中全基因组关联研究 (GWAS) 的仪器变量进行双样本孟德尔随机化 (MR).
使用多变量MR (MVMR) 来评估调解效应.
进行敏感性分析以确保调查结果的可靠性.

主要成果:

增加的内在表观遗传年龄加速 (HorvathAge) 与较高的初级开角玻璃眼风险相关.
汉纳姆Age的表观遗传年龄加速 (EEA) 与降低初级闭角玻璃眼风险和降低中心角膜厚度有关.
特定的DNA甲基化模式与长视,视网膜脱落,与年龄相关的黄斑变性和眼内压力等疾病有关.

结论:

建立了表观遗传钟与各种与年龄有关的眼睛疾病之间的因果关系.
需要进一步的研究来阐明连接衰老过程和AREDs的潜在生物机制.

关键词:

与年龄相关的白内障生物衰老生物衰老中部角膜的厚度角膜的厚度基因表观时钟是什么?眼光障碍症眼光障碍症眼光障碍症门德尔的随机化

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