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Updated: Jun 17, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
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免疫细胞身份的丧失随着年龄的增长从单细胞转录组的大型图谱中推断出来

Erin Connolly1, Tony Pan2,3, Maneesha Aluru2

  • 1Center for Integrative Genomics, and School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.

Aging cell
|August 15, 2024
PubMed
概括

衰老导致免疫细胞,特别是效应性和细胞毒性类型,失去其独特的身份,导致细胞多样性增加. 这种免疫衰老在不同性别和年龄之间是一致的,影响免疫功能和潜在的治疗方法.

关键词:
计算管道的计算管道不同的表达方式,不同的表达方式.免疫细胞衰老 免疫细胞衰老周围血液中的单核细胞.我们的 scRNAseqq.

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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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