益生菌通过调节TLR2/MyD88/NF-κB信号通路来抑制LL37产生的类似疹的皮肤炎症
Xinyue Qi1,2,3, Yiran Xiao4, Xinfeng Zhang2
1School of Life Sciences, Nanchang University, Nanchang, China. chentingtao1984@163.com.
益生菌 Ligilactobacillus salivarius 23-006 和 Lacticaseibacillus paracasei 23-008 通过调节肠道微生物群和抑制炎症途径,有效治疗粉红疹. 这项研究为这种慢性皮肤疾病提供了新的治疗方法.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 粉红是一种慢性炎症性皮肤疾病,与肠道微生物群失调有关.
- 肠道细菌和红病原体之间的相互作用是一个新兴的研究领域.
- 凯瑟利西丁LL37和TLR2/MyD88/NF-κB通路与粉红病的发展有关.
研究的目的:
- 为了评估 Ligilactobacillus salivarius 23-006 和 Lacticaseibacillus paracasei 23-008 益生菌在粉红病小鼠模型中的疗效.
- 研究这些益生菌及其后生菌对肠道微生物群和炎症通路的影响.
- 探索这些益生菌作为治疗的治疗策略的潜力.
主要方法:
- 从健康的志愿者中分离和选L. salivarius 23-006和L. paracasei 23-008.
- 在干预研究中构建一个LL37诱导的粉红类似的小鼠模型.
- 评估皮肤病变,炎症标志物,肠道微生物群组成 (16S rRNA分析) 和信号通路激活 (TLR2/MyD88/NF-κB).
主要成果:
- 在小鼠中,L. salivarius 23-006和L. paracasei 23-008都减轻了类似疹的症状,减少了炎症,并减少了炎症因素.
- 两种益生菌菌株的组合显示出最显著的改善,抑制TLR2/MyD88/NF-κB通路和LL37表达.
- 益生菌治疗增强了肠道屏障功能,恢复了微生物群的平衡,增加了乳酸菌的丰富性,并减少了Coprococcus和Oscillospira.
结论:
- L. salivarius 23-006和L. paracasei 23-008通过调节肠道微生物群和炎症通路,显示出对粉红的显著治疗潜力.
- 这些益生菌的组合提供了一个有前途的策略,用于管理rosacea.
- 这项研究为使用特定益生菌菌株治疗粉红病提供了科学依据.
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