Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Crizotinib or vebreltinib response and resistance in advanced non-small cell lung cancer with MET exon 14 skipping.

Discover oncology·2026
Same author

Exploratory Identification of Gene Copy Number Cut-Off for NGS-Based <i>MET</i> Amplification Assessment and Clinical Relevance to MET Inhibitor Outcomes in Non-Small-Cell Lung Cancer.

Lung Cancer (Auckland, N.Z.)·2026
Same author

Abnormal cortical hierarchy revealed by gradient dysfunction in patients with definite amyotrophic lateral sclerosis.

Brain research bulletin·2026
Same author

Gotistobart or docetaxel in metastatic squamous non-small cell lung cancer: stage 1 of the randomized phase 3 PRESERVE-003 trial.

Nature medicine·2026
Same author

Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression.

BMC medicine·2026
Same author

Clinical Progression Modes of Crizotinib Failure and Subsequent Management of Advanced Non-Small Cell Lung Cancer With ROS1 Rearrangement.

Cancer medicine·2026

相关实验视频

Updated: Jun 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K

皮质微观结构异常在肌缩侧面硬化症:一个基于灰色质的空间统计学研究研究.

Xin-Yun Xiao1, Jing-Yi Zeng1, Yun-Bin Cao1

  • 1Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.

Quantitative imaging in medicine and surgery
|August 15, 2024
PubMed
概括

肌缩侧面硬化症 (ALS) 涉及灰色物质的微观结构变化,特别是皮质区域的神经元密度指数 (NDI) 和方向分散指数 (ODI) 的降低. 这些变化与疾病严重程度相关,这表明NODDI是潜在的生物标志物.

关键词:
肌缩侧面硬化症 (ALS) 是一种疾病.皮层的微观结构.基于灰色物质的空间统计 (GBSS)神经元的定向分散和密度成像 (NODDI)神经退行症的神经退行症

更多相关视频

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K
Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
06:48

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images

Published on: January 7, 2019

8.9K

相关实验视频

Last Updated: Jun 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.6K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K
Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
06:48

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images

Published on: January 7, 2019

8.9K

科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 生物标志物 生物标志物

背景情况:

  • 肌缩侧面硬化症 (ALS) 的特点是白质异常,但灰质变化仍然不太了解.
  • 研究皮质微结构异常对于全面了解ALS病理学至关重要.

研究的目的:

  • 用先进的神经成像技术评估ALS患者皮质微结构异常.
  • 确定这些微观结构变化与ALS疾病严重程度之间的关联.

主要方法:

  • 使用扩散权重成像来估计神经元导向分散和密度成像 (NODDI) 参数 (NDI和ODI).
  • 采用基于灰色质的空间统计 (GBSS) 来对皮层微观结构进行素分析.
  • 相关的NODDI参数与ALS功能评级尺度修订 (ALSFRS-R) 评分.

主要成果:

  • 在多个皮层区域观察到NDI的显著减少,包括前中心,皮和前额叶皮.
  • 在某些特定区域,如前中心和下叶,观察到ODI的减少.
  • 在左前中枢和后中枢环中进行的NDI显示与ALS疾病严重程度有正相关性.

结论:

  • 在ALS中存在灰质微观结构损伤,以运动和非运动区域的NDI和ODI减少为标志,在ALS中存在.
  • NODDI参数显示出作为评估ALS疾病进展的体内成像生物标志物的前景.
  • GBSS是一种有效的方法来检测ALS的皮质微结构异常.