在精神病的早期阶段,皮层网络的破坏是最小的
Peter C Van Dyken1, Michael MacKinley2, Ali R Khan3,4
1Neuroscience Graduate Program, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Schizophrenia bulletin open
|August 15, 2024
概括
精神分裂症的白质变化在第一发精神病 (FEP) 患者中是最小的,与已确定的疾病形成鲜明对比. 早期精神病患者没有显著的拓网络变化,这表明这些大脑变化在疾病晚期发展.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 精神分裂症与白质干扰和改变大脑连接性有关.
- 这些大脑变化的进展从第一个情节精神病 (FEP) 到已确定的疾病还不清楚.
- 现有的扩散磁共振成像 (dMRI) 研究显示,关于早期精神病的脑部变化,结果各不相同.
研究的目的:
- 研究精神分裂症中白质和皮质网络变化的轨迹.
- 为了将第一发精神病 (FEP) 患者的脑部变化与已确定的精神分裂症患者和健康对照者的脑部变化进行比较.
- 为了确定在精神病发作时是否存在微观结构和拓学大脑变化.
主要方法:
- 获得了7TMRI扫描 (扩散和T1加权) 来自112名个人 (58名FEP,17名已确定的精神分裂症,37名对照).
- 采用基于voxel和网络的分析来评估扩散微结构参数.
- 利用图形理论指标来分析皮质网络层次结构和枢纽漏洞.
- 使用人类连接组项目-早期精神病 (HCP-EP) 数据集 (N=111) 的复制分析.
主要成果:
- 在已确定的精神分裂症中观察到广泛的微观结构变化,但在FEP患者中是最小的.
- FEP患者在皮质网络中没有显著的拓变化.
- 复制分析证实,在大多数指标上,早期精神病患者基本上与对照人群无法区分.
结论:
- 与精神分裂症相关的显著白质结构变化在疾病的早期阶段并不突出.
- 皮质网络的拓重组似乎是精神分裂症的后期发展.
- 这些发现表明,精神分裂症的脑部变化随着时间的推移而演变,而不是在精神病发作时完全存在.
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