当前的听觉幻觉与精神分裂症中的特定白质扩散变化无关
Stener Nerland1,2, Nora Berz Slapø2, Claudia Barth1,2
1Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Schizophrenia bulletin open
|August 15, 2024
概括
精神分裂谱系障碍 (SCZ) 中的听觉幻觉 (AH) 并没有与语言和听觉处理回路白质变化有具体联系. 扩散张力成像 (DTI) 在没有当前AH的患者中发现了广泛的微观结构差异.
科学领域:
- 神经成像是一种神经成像.
- 精神分裂症谱系障碍 精神分裂症谱系障碍
- 白物质的微观结构
背景情况:
- 精神分裂谱系障碍 (SCZ) 中的听觉幻觉 (AH) 通常与语言和听觉处理电路 (LAPC) 中的白质变化有关.
- 与AH相关的LAPC白质变化的特异性仍然不清楚.
研究的目的:
- 在SCZ患者中使用扩散张力成像 (DTI) 调查AH和白质微观结构之间的关系.
- 为了确定是否DTI变化是特定于LAPC在患者经历AH.
主要方法:
- 包括具有 (AH+) 和没有 (AH-) 当前AH的SCZ患者和健康对照.
- 从39个纤维通道中提取了DTI指标 (FA,MD,RD,AD).
- 使用主要成分分析 (PCA) 和回归模型来比较群体之间的DTI指标和PCA因子,并评估临床关联.
主要成果:
- 与对照组相比,没有当前AH (AH-) 的患者在平均扩散率 (MD) 和辐射扩散率 (RD) 中表现出广泛的差异.
- 在AH (AH+) 患者和对照人群之间,只发现了有限的DTI差异.
- PCA因子与AH-患者的对照有显著差异,但与AH+患者不同.
结论:
- 与之前的研究相反,DTI指标的变化在没有当前AH的SCZ患者中更为突出,这表明神经解剖学分布广泛.
- 这些发现挑战了在LAPC中改变的DTI指标是SCZ中AH的特定神经相关的假设.
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