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富含黄胺的丝丝的抗氧化和胆固醇调节作用

Ji Hae Lee¹, Yeon-Ji Kim², Kyungho Kim²

¹Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365 South Korea.

Food science and biotechnology

|August 15, 2024

概括

富含黄类的有色素丝虫提取物 (YN) 显示出强大的抗氧化剂和降胆固醇作用. 通过抑制胆固醇合成中的关键酶,YN减少了LDL胆固醇和肝脏胆固醇的积累.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
营养保健品营养保健品

背景情况:

胆固醇对细胞膜和激素产生至关重要,但高水平会导致疾病.
丝虫子含有具有潜在健康益处的生物活性化合物.
通过比较有色素和白色丝虫,发现了独特的生物活性.

研究的目的:

为了比较有色素和白色丝虫子的生物活性.
为了研究从Yeonnokjam (YN) 丝虫品种中提取的素提取物的降胆固醇潜力.
为了阐明YN降低胆固醇效应背后的分子机制.

主要方法:

从有色素和白色丝虫子中提取和比较生物活性物质.
评估抗氧化活性和抑制胆固醇生物合成酶.
在体内研究,使用YN养的小鼠测量血清脂质概况和肝脏胆固醇水平.
西方斑分析用于量化关键胆固醇合成蛋白的表达.

主要成果:

耶诺诺克贾姆 (YN) 丝虫提取物表现出高黄素含量,优异的抗氧化活性,并显著抑制胆固醇生物合成酶.
用YN养的小鼠显示血清低密度脂蛋白胆固醇减少了26%,肝脏胆固醇积累减少了27%.
YN显著降低了3-基-3-甲基氨基-CoA减少酶 (34%) 和乙烯基-CoA乙烯基转移酶2 (13%).

结论:

YN丝虫囊提取物有效地抑制肝脏中的胆固醇合成.
YN刺激胆汁酸的分泌,有助于降低胆固醇水平.
黄显示出作为一种天然降胆固醇剂的显著潜力.

关键词:

生物活性生物活性胆固醇的新陈代谢子中的子功能性食品是一种功能性食品.耶诺克贾姆丝虫是什么意思

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