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从酸奶中分离出来的细菌代谢物的抗泡细胞活性

Soudipta Pramanik¹, Alok Kumar Sil¹

¹Department of Microbiology, University of Calcutta, 35, Ballygunge Circular Road, Ballygunge, Kolkata, 700019 India.

Food science and biotechnology

|August 15, 2024

概括

酸奶细菌代谢物阻止泡细胞的形成,这是动脉样硬化发展的关键一步. 这些化合物显示出治疗这种主要人类杀手的治疗潜力.

科学领域:

微生物学微生物学
生物化学生物化学
心血管科学心血管科学

背景情况:

益生菌对动脉样硬化有前途,但水平基因转移是一个局限性.
研究正在转向研究益生菌衍生代谢物以获得治疗益处.
泡细胞的形成是动脉样硬化发展的一个关键事件.

研究的目的:

为了研究从酸奶中分离出来的细菌中的代谢产物对atherogenic的抗作用.
为了确定这些代谢物对泡细胞形成的影响.
为了阐明作用的潜在机制.

主要方法:

从酸奶中分离出一种细菌.
制备无细胞条件介质 (CM) 和其二甲提取物 (CME).
对泡细胞形成和预制泡细胞的CM和CME的评估.
气色谱-质谱学 (GC-MS) 分析以识别化合物.
评估CME的抗氧化和抗NF-κB活性.

主要成果:

酸奶分离物的CM和CME抑制了泡细胞的形成.
CM和CME降低了预制泡细胞的水平.
GC-MS确定了具有已知的抗异原性质 (抗氧化剂,抗NF-κB,脂溶性) 的化合物.
CME表现出显著的抗氧化和抗NF-κB活性.

结论:

来自隔离的酸奶细菌的代谢物具有显著的抗atherogenic特性.
这些代谢物有效地防止和减少泡细胞的形成.
这些发现表明,这些细菌代谢物在治疗动脉样硬化时具有治疗潜力.

关键词:

抗氧化剂是一种抗氧化剂.动脉样硬化是一种动脉样硬化.炎症性炎症性炎症性代谢物的代谢物.益生菌是一种益生菌.

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