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聚烯亚类与前列腺癌之间的关联:观察性研究的系统审查和元分析

Yiping Huang¹, Wenyan Wang², Jianxiang Jin³

¹Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.

Frontiers in nutrition

|August 15, 2024

概括

饮食中的多醇,特别是黄醇,黄醇和氨酸,与更高的前列腺癌 (PCA) 风险有关. 然而,血清/血多,如基因斯坦和肠乳,显示PCA的风险降低.

科学领域:

营养科学营养科学
在瘤学瘤学.
流行病学流行病学

背景情况:

各种多类对前列腺癌 (PCA) 的影响仍然是争论的主题.
调查多类和PCA发病率之间的关联对于了解饮食对癌症风险的影响至关重要.

研究的目的:

系统地评估饮食,血清/血和尿路聚烯子类与前列腺癌发病率之间的关系.
为了澄清聚醇对PCA风险的有争议的影响.

主要方法:

在主要数据库 (PubMed,科学网,Embase,Cochrane图书馆) 进行了全面的系统搜索,截至2023年12月.
包括38个观察性研究 (11个队列,27个病例控制) 与824,933名参与者.
分析使用调整的几率比率 (OR) 和95%置信区间 (95%CI) 来评估关联.

主要成果:

饮食中的多醇,特别是黄醇,黄醇和氨酸,与PCA风险显著增加有关 (OR=1.01-1.06).
在饮食中的多醇和非局部或高档PCA之间没有发现显著的关联.
血清/血总聚醇,基因斯坦和肠乳与PCA风险降低有关 (OR=0.92-0.95).

结论:

多似乎通常会增加男性的前列腺癌风险,其影响因子类和形式而异 (饮食与血清/血).
饮食中摄入某些多可能会增加PCA风险,而血清/血水平可能会提供保护.
需要进一步的研究来阐明多类子类之间的复杂相互作用,它们的生物可用性和PCA发展.

关键词:

这是一个元分析.它是一种植物性雌激素.聚烯子类是多烯子类中的一个.前列腺癌是前列腺癌.风险评估风险评估风险评估

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