淋巴细胞的动态衰退预测了与体外膜氧化相关的感染:一项回顾性观察性研究
Tong Hao1, Chenhui Jin1, Dingji Hu1
1Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Journal of thoracic disease
|August 15, 2024
概括
身体外膜氧化 (ECMO) 患者面临感染的高风险,呼吸机相关的肺炎是最常见的. 淋巴细胞数量的下降是ECMO相关感染的关键预测因素.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 医学微生物学 医学微生物学
背景情况:
- 关于中国ICU中体外膜氧化 (ECMO) 相关感染的数据有限.
- 这项研究调查了ECMO相关感染的流行病学,风险因素和结果.
研究的目的:
- 确定ECMO相关感染的发病率和特征.
- 确定与这些感染相关的风险因素.
- 评估ECMO相关感染对患者结果的影响.
主要方法:
- 成年患者接受ECMO治疗超过48小时 (2014年1月至2019年12月) 的回顾性观察研究.
- 收集关于临床特征,感染发展和结果的数据.
- 统计分析以确定风险因素和对死亡率的影响.
主要成果:
- 包括174名患者,26.4%患有ECMO相关的感染 (27.5次/1,000个ECMO日).
- 呼吸机相关肺炎 (VAP) 是最常见的感染.
- 受感染的患者有更长的机械通风,ECMO和住院时间,死亡率更高.
- 淋巴细胞数量的动态下降和更长的ECMO持续时间是独立的风险因素.
- 感染显著恶化了医院和90天死亡率.
结论:
- 对于ECMO患者来说,感染的风险很高.
- VAP是ECMO相关的主要感染.
- 淋巴细胞数量的动态下降是ECMO相关感染风险的重要预测因素.
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