与间歇性肺部疾病相关的多聚炎/皮质炎复发的预测因素
Tomoo Kishaba1, Hiroyuki Yano2, Masaki Itagane2
1Department of Respiratory Medicine, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.
Journal of thoracic disease
|August 15, 2024
概括
在CT扫描上,高血清乳酸脱酶 (LDH) 水平和磨砂玻璃不透明度 (GGO) 预测了多聚炎/皮肤肌炎相关的间歇性肺病 (PM/DM-ILD) 的复发. 这些标记可以帮助识别患有疾病复发风险的患者.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 医疗成像医学成像
背景情况:
- 多髓炎/皮质髓炎 (PM/DM) 经常导致间歇性肺病 (ILD).
- 尽管使用抗炎药物治疗,但PM/DM相关ILD的复发可能会发生.
- 了解复发特征对于患者管理至关重要.
研究的目的:
- 为了确定与PM/DM-ILD患者复发相关的临床特征.
- 为了确定这种患者群体中复发的预测因素.
主要方法:
- 从2010年至2018年期间治疗的74名PM/DM-ILD患者的临床数据的回顾性分析.
- 包括实验室结果,肺功能测试和胸部HRCT发现.
- 使用Cox比例危险模型和ROC曲线分析进行统计分析.
主要成果:
- 在74名患者中,36名患者经历了复发,尽管接受了免疫抑制疗法.
- 复发的患者年轻,并且更频繁地报告肌痛和皮疹.
- 在复发患者中观察到较高的血清乳酸脱酶 (LDH) 水平和HRCT上磨砂玻璃不透明度 (GGO) 的患病率.
- 血清LDH和GGO是复发的显著预测因素 (P=0.02).
结论:
- 在HRCT上的血清LDH和GGO是PM/DM-ILD复发的潜在预测因素.
- 鉴定了450U/L的血清LDH值,用于分类复发风险.
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