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COVID-19 血清阳性捐赠者产生可比的肺移植后结果

Chitaru Kurihara¹, Taisuke Kaiho¹, Takahide Toyoda¹

¹Division of Thoracic Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Journal of thoracic disease

|August 15, 2024

概括

过去患有COVID-19感染的捐赠者的肺部是安全的移植. 使用COVID-19血清阳性捐赠者的肺部移植的接受者与血清阴性捐赠者的肺部移植者相比,显示出相似的生存率和结果.

科学领域:

移植免疫学移植免疫学
传染病研究传染病研究.
肺部医学肺部医学

背景情况:

COVID-19可能会导致持续的肺炎和纤维化.
使用COVID-19幸存者的肺部进行移植的安全性是令人担忧的.

研究的目的:

确定使用COVID-19血清阳性捐赠者的肺部进行肺移植的安全性和可行性.
为了比较COVID-19血清阳性和血清阴性捐赠者的肺接受者之间的移植后结果.

主要方法:

一个单一中心的研究涉及90个肺移植手术.
在捐赠者中进行COVID-19血清学标准化免疫学测试.
基于捐赠者COVID-19血清状态的接受者结果的比较.

主要成果:

从血清阳性和血清阴性捐赠者的接受者之间,移植后生存率没有显著差异.
主要移植功能障碍和其他临床参数 (例如,重症监护室停留,住院停留) 的比较率.

结论:

来自COVID-19病毒阳性捐赠者的肺 (过去的感染) 对于移植是安全的.
利用有COVID-19感染史的捐赠者的器官可以扩大捐赠者池,而不会影响患者的结果.

关键词:

冠状病毒疾病2019年 (COVID-19) 是一个疾病.肺部移植是一项肺移植.主要移植功能障碍 (PGD)

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