间歇性肺病的急性恶化和冷活检后的死亡率:一个多中心队列研究
Adam Austin1, Johnny Jaber1, Katherine Fu1
1Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Journal of thoracic disease
|August 15, 2024
概括
在肺结核检查后,3.6%的患者出现了间歇性肺病 (AE-ILD) 的急性恶化. 虽然冷活检可能会降低死亡率,但AE-ILD风险需要仔细选择患者并进行进一步研究.
科学领域:
- 肺部病理学 肺部病理学
- 干预性肺病学 干预性肺病学
- 诊断程序 诊断程序 诊断程序
背景情况:
- 间歇性肺部疾病 (ILD) 是一组影响肺部结构的肺部疾病.
- 医学术后的ILD急性恶化 (AE-ILD) 是一个重大的临床问题.
- 有限的数据存在AE-ILD在肺冷试验通过支气管活检 (冷活检) 后.
研究的目的:
- 为了检查冷活检后AE-ILD的患病率.
- 为了确定与AE-ILD冷活检后相关的风险因素.
- 为了评估AE-ILD在冷活检后的结果.
主要方法:
- 多中心回顾性研究分析了来自美国三所机构的数据 (2014年1月至2022年8月).
- 包括18岁以上的确诊或疑似ILD的患者,他们接受了冷活检.
- 患者被分为经历AE-ILD冷活检后患者和没有经历AE-ILD的患者.
主要成果:
- 在111名患者中,3.6%患有AE-ILD,这一亚组的死亡率为50%.
- 患有AE-ILD的患者的活检中位数较高.
- 整体30天死亡率为1.8%;整体并发症率为32%.
结论:
- 与某些ILD患者的手术肺活检相比,冷活检可能与较低的整体死亡率有关.
- 低温活检后AE-ILD的高风险凸显了需要仔细选择患者和程序评估的需要.
- 需要进一步的研究来优化患者的治疗结果和在ILD诊断中进行冷活检的程序安全性.
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