在肺切除后胃食道逆流的发病率的试点研究
Toshiko Kamata1,2, Shigetoshi Yoshida1,2, Yuji Tada3
1Department of Thoracic Surgery, International University of Health and Welfare, School of Medicine, Narita, Japan.
Journal of thoracic disease
|August 15, 2024
概括
肺切除手术可以增加胃食道逆流 (GER) 的风险. 患有较大的切除或肺功能显著下降的患者表现出持续升高的唾液素,这表明手术后GER风险更高.
科学领域:
- 胸部外科手术 胸部外科手术
- 胃肠病学 胃肠病学
- 肺部医学 肺部医学
背景情况:
- 肺切除手术对患者构成风险,包括胃食道逆流 (GER) 和静音吸收.
- 识别患有高风险的GER和志向患者对于制定预防策略至关重要,以避免恶化肺部疾病.
研究的目的:
- 为了调查术后胃食道逆流性疾病 (GERD) 症状的发生,并测量肺切除后患者的唾液中素度.
- 在接受肺部手术的患者中确定术后GERD标志物升高的预测因素.
主要方法:
- 一项试点研究涉及50名接受肺切除的患者.
- 患者在手术前和出院时填写了GERD症状问卷.
- 手术前,手术后的第三天和出院时收集唾液样本,使用Peptest测量素度.
主要成果:
- 唾液辛度在术后第三天显著升高,但在大多数患者中,随着出院而正常化.
- 经过切除四个或更多肺子段的患者,或强迫呼气体积减少超过10%的患者,表现出持续升高的唾液素.
- 相当于或大于右中叶切除术的切除与唾液素持续增加有关.
结论:
- 肺切除可以导致唾液素升高,表明胃食道逆流.
- 肺切除的程度,特别是大体积,可能通过解剖学和呼吸模式的变化导致GER.
- 监测素水平可以帮助识别肺部手术后GER的高风险患者.
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