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Updated: Jun 16, 2025

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
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纳米材料生理学基础的药动力学 (PBPK) 建模的进展

Ozlem Ozbek1, Destina Ekingen Genc1, Kutlu O Ulgen1

  • 1Chemical Engineering Department, Bogazici University, Bebek 34342 Istanbul, Turkey.

ACS pharmacology & translational science
|August 15, 2024
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模有助于理解纳米粒子 (NP) 在身体中的行为. 本综述探讨了PBPK对NP的应用,增强药物输送和预测毒性.

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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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