肝细胞癌药物耐药性模型的进展
Yien Xiang1, Jun Wu1, Hanjiao Qin2
1Department of Hepatobiliary and Pancreatic Surgery, the Second Hospital of Jilin University, Changchun, China.
Frontiers in medicine
|August 15, 2024
概括
肝细胞癌 (HCC) 耐药性对有效治疗构成了挑战. 本综述探讨了in-vivo和in-vitro模型,以了解耐药性机制,并指导个性化HCC治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 药物发现 药物发现 药物发现
背景情况:
- 肝细胞癌 (HCC) 是一种普遍存在的原发性肝癌,通常通过手术治疗.
- 手术的疗效受到瘤复发和转移的限制,需要全身疗法.
- 新型向和免疫疗法改善了先进的HCC预后,但由于瘤异质性和耐药性而面临挑战.
研究的目的:
- 综合审查已建立的肝细胞癌 (HCC) 耐药性的体外和体外模型.
- 了解HCC治疗中耐药性背后的机制.
- 为开发个性化HCC治疗提供一个模型基础.
主要方法:
- 对已建立的体外和体外模型进行审查,以研究肝细胞癌 (HCC) 的耐药性.
- 分析这些模型在理解阻力机制方面的应用.
- 探索这些模型如何为个性化治疗策略提供信息.
主要成果:
- 确定并审查了在HCC耐药性研究中使用的各种体外和体外模型.
- 强调了这些模型在阐明抗性机制方面的重要性.
- 强调了建模在为个性化HCC治疗铺平道路中的作用.
结论:
- 耐药性仍然是肝细胞癌 (HCC) 治疗的重要障碍,尽管系统疗法取得了进展.
- 活体和体外模型是剖析HCC耐药性机制的关键工具.
- 这些模型的进一步开发和应用对于推进个性化HCC治疗策略至关重要.
更多相关视频
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
08:40A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
6.2K
相关概念视频
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K