在患有非影响性和影响性早期疾病精神病症的个体中,皮层和皮下结构形态学概况
Jessica P Y Hua1,2,3, Daniel H Mathalon2,3
1Sierra Pacific Mental Illness Research Education and Clinical Centers, San Francisco VA Medical Center, and the University of California, San Francisco, CA, USA.
Schizophrenia bulletin open
|August 15, 2024
概括
早期的精神病研究揭示了非影响性和影响性精神病中明显的脑结构差异. 这些发现突出了共同和独特的大脑异常,对于了解早期疾病进展至关重要.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑形态测量 - - 大脑形态测量
背景情况:
- 精神病,包括非影响性 (NAff-P) 和影响性 (Aff-P) 类型,呈现出复杂的大脑异常.
- 慢性和药物效应可能会混早期精神病研究,需要对疾病早期阶段进行研究.
研究的目的:
- 调查和比较早期非情感精神病和情感精神病中的结构性大脑形态特征.
- 为了确定这些早期精神病群体中常见和明显的区域性脑部异常.
主要方法:
- 利用人类连接组项目-早期精神病数据进行多变量分析.
- 在健康对照组,早期NAff-P和早期Aff-P组中检查了皮层厚度,表面积,皮下体积和心室体积的区域概况.
- 考虑了正常的衰老,并分析了与症状严重程度,功能和认知的关联.
主要成果:
- 在健康对照组,NAff-P组和Aff-P组之间观察到皮层厚度和表面积的显著差异.
- NAff-P显示出广泛的皮质稀释,而Aff-P和NAff-P在表面积方面与对照组和彼此不同.
- 发现了明显的皮层下体积异常,NAff-P表现出扩大的白体和较小的accumbens/海马体,而Aff-P显示较小的accumbens/杏仁体.
- 与对照组和Aff-P相比,NAff-P观察到心室膨胀,心室体积较大与躁狂症状相关.
结论:
- 早期的非影响性和情感性精神病表现出常见和独特的区域形态度大脑异常.
- 这些发现表明,在早期精神病中,病理生理过程与疾病特异性变化共同存在.
- 了解这些早期的结构差异对于有针对性的干预和治疗策略至关重要.
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