在过渡到精神病的过程中,失成熟的纵向表观遗传衰老
Anton Iftimovici1,2, Oussama Kebir1,3, Chuan Jiao1
1Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, GDR 3557-Institut de Psychiatrie, Pathophysiology of psychiatric disorders, Paris, France.
Schizophrenia bulletin open
|August 15, 2024
概括
在转化为精神病期间表观遗传年龄加速可能表明神经发育不成熟. 这一发现为精神病风险和风险青少年出现的潜在生物标志物提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 精神病通常在青春期和年轻成年期出现.
- 基因与环境的相互作用,通过像DNA甲基化这样的表观遗传机制来调解,与精神病的发展有关.
- 源自DNA甲基化模式的表观遗传年龄可以作为神经发育轨迹和精神病风险的生物标志物.
研究的目的:
- 进行第一个纵向分析表观遗传年龄轨迹在超高风险的个体精神病.
- 研究表观遗传加快年龄作为转化为精神病的潜在指标.
- 探索表观遗传衰老和精神病中的神经发育过程之间的关系.
主要方法:
- 基因组范围内的DNA甲基化数据在基线和一年的随访期间从38名患有精神病超高风险的人群中收集.
- 使用甲基化模式预测表观遗传年龄.
- 计算和分析了与精神病转换相关的表观遗传年龄差距和纵向表观遗传年龄加速.
主要成果:
- 在基线,后来转化为精神病的个体在表观遗传上比非转化者更年轻.
- 在一年的随访期间,与非转换者相比,转换者显示出显著的表观遗传年龄加速 (2.8年/年).
- 在调整年龄,性别和大麻使用后,这种加速仍然显著,并且与精神分裂症和神经发育障碍相关的基因有关.
结论:
- 纵向表观遗传年龄加速是一种与风险人群转化为精神病相关的强有力的发现.
- 这种加速衰老的轨迹,可能是在早期减速之后,可能反映了精神病神经发育中的不成熟过程.
- 表观遗传年龄加速可以作为精神病风险和出现的可测量的替代标记,为其神经发育模型提供见解.
关键词:
没有成熟,不成熟.遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表甲基化处理的方法神经发育的神经发育这是超高风险的超高风险.
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