相关实验视频
Updated: Jun 16, 2025
10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
19.4K
在患有支气管喘的儿童中,肠道微生物群和益生菌干预
Xiaodan Chen1, Su-Boon Yong2, Chin-Yuan Yii3,4
1Ningbo Medical Center LiHuiLi Hospital, The Affiliated LiHuiLIi Hospitai of Ningbo University, Zhejiang, China.
Heliyon
|August 15, 2024
概括
儿童喘与肠道细菌失衡有关. 益生菌有效地恢复肠道菌群,改善免疫标志物,为儿童喘提供有前途的辅助治疗.
科学领域:
- 儿科过敏和免疫学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 儿童支气管喘与肠道菌群的变化和免疫系统失调有关.
- 特定的细菌属如 Bacteroides, Faecalibacterium 和 Veillonella 在喘儿童中显示出改变的丰度.
- 在患有喘的儿童中观察到高水平的IgE,某些细胞因子 (IL-4,IL-5,IL-9,IL-13) 和降低的Th1/Th2比率.
研究的目的:
- 为了研究患有支气管喘和没有支气管喘的儿童之间的肠道菌群,T细胞表达,过敏指标和细胞因子水平的差异.
- 评估益生菌制剂作为治疗儿童支气管喘的疗效和安全性.
- 确定用于治疗儿科支气管喘的新型治疗策略.
主要方法:
- 一项队列研究比较66名患有喘的儿童 (3-6岁) 和35名健康儿童.
- 喘组分为益生菌和非益生菌子组进行分层进行比较分析.
- 对肠道微生物群组成,血清IgE,细胞因子 (IL-4,IL-5,IL-9,IL-13),Th1/Th2细胞比例和C反应蛋白的分析.
主要成果:
- 患有喘的儿童表现出肠道菌群多样性的减少和关键品种的丰富性变化 (增加Bacteroides,减少Faecalibacterium和Veillonella).
- 与非益生菌组相比,益生菌干预显著改善了这些肠道细菌的丰富性.
- 免疫标志物显著改善,包括血清IgE,IL-4,IL-5,IL-9和IL-13的降低,以及Th1/Th2比率的增加,特别是在益生菌组中观察到.
结论:
- 患有支气管喘的儿童表现出肠道失调,其特点是特定的细菌失衡,这与过敏性疾病的风险增加有关.
- 益生菌补充剂有效调节肠道微生物群,有助于儿童免疫平衡.
- 益生菌是一种有价值的辅助疗法,可以改善儿科支气管喘的结果.
相关概念视频
01:23Anatomy of the Intestines
71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
255
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
255
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:29Bacterial Flora of the Large Intestine
404
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
404
01:20Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K