相关实验视频
Updated: Jun 16, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
393
喉状细胞癌中枢基因和关键模块的鉴定
Hongyue Li1, Shaojun Bo1, Yutian Guo1
1Department of Otolaryngology Head and Neck Surgery, Civil Aviation General Hospital (Peking University Civil Aviation School of Clinical Medicine), Beijing, China.
Translational cancer research
|August 15, 2024
概括
这项研究确定了喉平细胞癌 (LSCC) 中的关键基因,以改善治疗. 低OAT和高CAV1表达显著影响患者的生存,提供潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 喉平细胞癌 (LSCC) 显著影响患者的生活质量.
- 目前的LSCC治疗方法 (化疗,手术,放射治疗) 对复发或持续病例的疗效有限.
- 目前尚不清楚LSCC的确切病原体,因此需要新的治疗点.
研究的目的:
- 为了识别与LSCC相关的枢纽基因.
- 探索LSCC的潜在治疗点.
- 了解LSCC进展背后的分子机制.
主要方法:
- 分析了来自TCGA和GEO数据库的全转录组高通量测序 (HTS) 数据.
- 进行了差异基因表达分析,加权基因同表达网络分析 (WGCNA),KEGG,GO和PPI网络分析.
- 确定了枢纽基因,并验证了它们的预后价值和蛋白质表达水平.
主要成果:
- 差异基因表达分析确定了2,139个 (GEO) 和2,774个 (TCGA) 差异表达基因 (DEG).
- WGCNA确定了13个 (TCGA-LSCC) 和15个 (GSE127165) 显著模块;检索了36个重叠的基因.
- 确定了10个网络枢纽基因,低OAT和高CAV1表达显著影响LSCC患者的存活率.
结论:
- 确定了与LSCC相关的关键枢纽基因和模块.
- 经过验证的枢纽基因,特别是OAT和CAV1,对于理解LSCC病原体至关重要.
- 这些发现突出了LSCC潜在的精确生物标志物和治疗点.
相关概念视频
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K

