纤维细胞骨肉瘤患者的生存率和预后因素的分析:基于人口的研究
Dongsheng Zhu1,2, Wen Zheng1, Han Qi3
1Department of Orthopedics, Children's Hospital of Soochow University, Suzhou, China.
Translational cancer research
|August 15, 2024
概括
高龄和先进的SEER阶段显著影响纤维细胞骨肉瘤 (FOS) 的整体存活率. 预测性诺米图准确预测FOS患者的生存概率.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 手术病理学手术病理学
背景情况:
- 纤维细胞骨肉瘤 (FOS) 是一种罕见的骨肉瘤亚型,是一种常见的骨癌.
- 由于其发病率较低,对影响FOS存活率的预后因素的数据有限.
- 了解生存率和风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 确定纤维细胞骨肉瘤 (FOS) 的当前生存率.
- 确定影响FOS存活率的病理和治疗相关风险因素.
- 开发一个用于FOS预后的预测模型.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库来获取患者数据.
- 收集了关于年龄,性别,种族,SEER阶段,手术,辐射,化疗和FOS地点的数据.
- 采用了卡普兰-梅尔分析,多变量考克斯回归,以及用于分析的预测名录.
主要成果:
- 1,3年和5年的总生存率分别为90.83%,79.17%和70.83%.
- 先进的SEER阶段,放射治疗和缺乏手术与更差的预后有关.
- 老年和高级SEER阶段被确定为不利预后的独立预测因素.
结论:
- 高龄和高级SEER阶段与FOS的整体存活率降低有关.
- 一个经过验证的诺姆图有效地预测了FOS患者的1年,3年和5年的整体生存期.
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